Aeglea Bio Therapeutics (AGLE) vs. Imprimis Pharmaceuticals (IMMY) Head to Head Review

Imprimis Pharmaceuticals (NASDAQ:IMMY) and Aeglea Bio Therapeutics (NASDAQ:AGLE) are both small-cap medical companies, but which is the better investment? We will compare the two businesses based on the strength of their risk, analyst recommendations, dividends, institutional ownership, earnings, valuation and profitability.

Volatility & Risk

Imprimis Pharmaceuticals has a beta of -1.06, indicating that its share price is 206% less volatile than the S&P 500. Comparatively, Aeglea Bio Therapeutics has a beta of 1.06, indicating that its share price is 6% more volatile than the S&P 500.

Earnings & Valuation

This table compares Imprimis Pharmaceuticals and Aeglea Bio Therapeutics’ gross revenue, earnings per share and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Imprimis Pharmaceuticals $26.77 million 0.00 -$11.98 million ($0.60) N/A
Aeglea Bio Therapeutics $3.89 million 54.60 -$44.35 million ($2.13) -3.46

Imprimis Pharmaceuticals has higher revenue and earnings than Aeglea Bio Therapeutics. Aeglea Bio Therapeutics is trading at a lower price-to-earnings ratio than Imprimis Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.

Institutional and Insider Ownership

16.1% of Imprimis Pharmaceuticals shares are owned by institutional investors. Comparatively, 56.9% of Aeglea Bio Therapeutics shares are owned by institutional investors. 13.8% of Imprimis Pharmaceuticals shares are owned by company insiders. Comparatively, 18.3% of Aeglea Bio Therapeutics shares are owned by company insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a stock is poised for long-term growth.

Analyst Recommendations

This is a breakdown of current recommendations for Imprimis Pharmaceuticals and Aeglea Bio Therapeutics, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Imprimis Pharmaceuticals 0 0 2 0 3.00
Aeglea Bio Therapeutics 0 1 3 0 2.75

Imprimis Pharmaceuticals presently has a consensus price target of $10.75, suggesting a potential upside of ∞. Aeglea Bio Therapeutics has a consensus price target of $24.00, suggesting a potential upside of 225.64%. Given Imprimis Pharmaceuticals’ stronger consensus rating and higher probable upside, analysts plainly believe Imprimis Pharmaceuticals is more favorable than Aeglea Bio Therapeutics.

Profitability

This table compares Imprimis Pharmaceuticals and Aeglea Bio Therapeutics’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Imprimis Pharmaceuticals -16.81% -231.16% -25.18%
Aeglea Bio Therapeutics N/A -71.39% -63.70%

Summary

Aeglea Bio Therapeutics beats Imprimis Pharmaceuticals on 7 of the 13 factors compared between the two stocks.

About Imprimis Pharmaceuticals

Imprimis Pharmaceuticals, Inc., an ophthalmology-focused pharmaceutical company, engages in the development, production, and sale of medications to physicians and patients in the United States. It offers ophthalmology focused compounding formulations; and sterile and non-sterile compounded medications. The company also develops and commercializes therapeutics for the ocular surface diseases. In addition, it provides patent-pending preservative-free topical eye drop drug candidates, including SURF-100, an immunosuppressive drug that inhibits t-cell proliferation and replication in the dry eye disease (DED); SURF-200 for the patients with episodic DED; and SURF-300, a combination of a low-dose of doxycycline and a proprietary powderized triglyceride Omega-3 for the refractory DED patients with chronic DED symptoms. The company was formerly known as Transdel Pharmaceuticals, Inc. and changed its name to Imprimis Pharmaceuticals, Inc. in February 2012. Imprimis Pharmaceuticals, Inc. was founded in 1998 and is headquartered in San Diego, California.

About Aeglea Bio Therapeutics

Aeglea BioTherapeutics, Inc., a clinical-stage biotechnology company, designs and develops human enzyme therapeutics for the treatment of patients with rare genetic diseases and cancer. The company's lead product candidate includes pegzilarginase, a recombinant human Arginase 1 enzyme, which is in early clinical development stage for the treatment of Arginase 1 deficiency, an autosomal recessive metabolic disease caused by a marked decrease in the activity of the native arginase 1 enzyme; and for treating Arginine dependent cancers. Its preclinical pipeline products comprise AEB4104, a recombinant human enzyme that degrades the amino acid homocysteine and its oxidized form homocysteine; AEB5100, a recombinant human enzyme that degrades plasma cystine and cysteine; AEB3103, an engineered human enzyme that targets the degradation of the amino acid cysteine/cysteine; and AEB2109, an engineered human enzyme that targets the degradation of the amino acid methionine. Aeglea BioTherapeutics, Inc. has a clinical collaboration agreement with Merck to evaluate the combination of pegzilarginase with Merck's anti-PD1 therapy, pembrolizumab, for the treatment of patients with small cell lung cancer. The company was formerly known as Aeglea BioTherapeutics Holdings, LLC and changed its name to Aeglea BioTherapeutics, Inc. in March 2015. Aeglea BioTherapeutics, Inc. was founded in 2013 and is headquartered in Austin, Texas.

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